Harlequin ichthyosis este o boala de piele sau stie naiba ce o fi... Sa va spun mai stiintific: este cea mai severa forma de congenital ichthyosis, caracterizat de ingrosarea cheratinei. Cei care sufera de aceasta boala se nasc cu niste solzi pe piele in forma de diamant care tind sa aiba culoarea rosiatica. În plus, ochii, urechile, gura, şi alte anexe pot fi contractate anormal.
Boala a fost cunoscuta pentru prima data in anul 1750, si a fost descrisa in jurnalul unui preot de la Charleston.
"On Thursday, April 5, 1750, I went to see a most object of a child, born the night before of one Mary Evans in 'Chas'town. It was surprising to all who beheld it, and I scarcely know how to describe it. The skin was dry and hard and seemed to be cracked in many places, somewhat resembling the scales of a fish. The mouth was large and round and open. It had no external nose, but two holes where the nose should have been. The eyes appeared to be lumps of coagulated blood, turned out, about the bigness of a plum, ghastly to behold. It had no external ears, but holes where the ears should be. The hands and feet appeared to be swollen, were cramped up and felt quite hard. The back part of the head was much open. It made a strange kind of noise, very low, which I cannot describe. It lived about forty-eight hours and was alive when I saw it."
Au fost raportate aproximativ 100 de cazuri de acest fel in toata lumea.